Table 2.

Selected adjusted ^* odds ratios (OR) and 95% confidence intervals (CI) between polymorphisms in genes on the chromosome 17q23 amplicon and breast cancer risk, Mayo Clinic, 2001-2005.

Gene/SNP rsID	Per allele	P trend	Homozygotes common allele (Referent)		Heterozygotes†			Homozygotes rare allele†			P 2f‡
	OR (95% CI)		Ca§	Co§	Ca	Co	OR (95% CI)	Ca	Co	OR (95% CI)
PRKCA
rs7342847	0.8 (0.7-1.0)	0.02	335	290	344	426	0.7 (0.6-0.9)	119	127	0.8 (0.6-1.1)	0.005
TBX4
rs11867179	0.8 (0.7-1.0)	0.04	445	451	310	319	1.0 (0.8-1.2)	43	73	0.6 (0.4-0.9)	0.03
rs3744448	1.2 (1.0-1.5)	0.03	559	634	217	189	1.3 (1.0-1.6)	22	20	1.3 (0.7-2.4)	0.08
TLK2
rs733025	0.8 (0.7-0.9)	0.006	378	345	339	395	0.8 (0.6-1.0)	81	103	0.7 (0.5-1.0)	0.02
rs12451705	0.8 (0.7-1.0)	0.02	260	226	374	427	0.7 (0.6-0.9)	163	189	0.7 (0.6-1.0)	0.02
rs6504112	0.8 (0.7-0.9)	0.008	314	285	365	404	0.8 (0.7-1.0)	119	154	0.7 (0.5-0.9)	0.03
rs2245092	0.8 (0.7-0.9)	0.005	356	325	357	405	0.8 (0.6-1.0)	85	113	0.7 (0.5-0.9)	0.02
YPEL2
rs16943468	1.3 (1.1-1.8)	0.03	679	745	113	95	1.3 (1.0-1.8)	6	3	2.1 (0.5-8.7)	0.10

^*Adjusted for age and region of residence.

^†Referent is homozygous common allele group.

^‡2-degree-of-freedom P value.

^§Ca, cases; Co, controls.