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. Author manuscript; available in PMC: 2009 Dec 26.
Published in final edited form as: Cell. 2009 Jun 26;137(7):1225–1234. doi: 10.1016/j.cell.2009.04.022

Figure 1. Chronic administration of bretazenil protects against starvation in adult mice after acute ablation of AgRP neurons.

Figure 1

(A) Percentage of initial body weight of DT-treated, AgrpDTR/+ mice after subcutaneous implantation of mini-osmotic pumps (mp) loaded with either bretazenil (n = 12) or vehicle (n = 10). DT was injected intramuscularly (im) twice as indicated by arrows. Minipumps were removed on Day 11 after drug solution was depleted.

(B) Liquid diet intake by the mice described in A.

(C) Licking activity of the mice described in A was plotted as average number of licks in 2-h bins. *, p < 0.01, ANOVA.

Error bars represent the standard error of mean (SEM).