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. Author manuscript; available in PMC: 2009 Dec 26.
Published in final edited form as: Cell. 2009 Jun 26;137(7):1225–1234. doi: 10.1016/j.cell.2009.04.022

Figure 5. Inhibition of GABAA receptors in the PBN or disruption of the neural inputs from AgRP neurons to the PBN produces anorexia.

Figure 5

(A) Percentage of initial body weight of C57BL/6 wild-type mice in which bicuculline (100, 300, and 1000 ng/day) was chronically infused to the PBN area through bilateral cannulae for 4 days and then discontinued.

(B) Intake of liquid diet by the mice described in A. *, p < 0.01, ANOVA between the groups of 100 ng/day and 1000 ng/day. Error bars represent the SEM. N = 5 – 6 mice per group.

(C) Percentage of initial body weight of AgrpDTR/+ and wild-type mice that received a single injection of DT into the PBN area (bilateral, 4 ng per side).

(D) Intake of liquid diet by the mice described in C.