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Representative outflow perfusate rate (picomoles per minute per gram of liver) of AG (•) and AS (▪) and biliary excretion rate (picomoles per minute per gram of liver) of AG (○) and AS (□) in male and female wild-type and Bcrp-deficient mouse livers. Livers were perfused with Krebs-Henseleit buffer containing 500 nM APAP for 40 min followed by an additional 30-min infusion with drug-free buffer. Curves represent the best fit of the model scheme depicted in Fig. 1 to the data.
