TABLE 1.

Mouse body weights, liver weights normalized to body weight, APAP extraction ratio, and total recovery at 70 min in in situ single-pass perfused livers from male and female wild-type and Bcrp-deficient mice

Livers were perfused with Krebs-Henseleit buffer containing 500 nM APAP for 40 min followed by an additional 30-min infusion with drug-free buffer. Data are the mean ± S.D. (n = 3–4/group).

	Wild-Type		Bcrp-Deficient
	Male	Female	Male	Female
Body weight (g)	28.4 ± 0.8*	25.8 ± 1.8*	25.9 ± 1.7	24.5 ± 1.7
Liver weight/body weight (%)	4.7 ± 0.2	4.8 ± 0.5	4.3 ± 0.2	4.4 ± 0.7
Extraction ratio (%)	35.4 ± 4.8	29.6 ± 7.1	30.8 ± 6.1	24.8 ± 1.2
Total recovery (% of dose)	98.4 ± 5.2	91.7 ± 8.5	93.6 ± 3.7	98.2 ± 4.8

^*Groups denoted with an asterisk were significantly different, p < 0.05.