. 2009 Jun 1;37(9):1916–1921. doi: 10.1124/dmd.109.026815

TABLE 2.

Mean pharmacokinetic parameter estimates governing APAP, AG, and AS disposition in in situ single-pass perfused livers from wild-type and Bcrp-deficient male and female mice

n = 3–4/group.

	Mean Estimates (CV %)
Parameter	Wild-Type	Brcp-Deficient
CL_up (ml/min)
Male	5.63 (12.1)	5.60 (13.2)
Female	5.79 (4.9)	5.55 (8.8)
K_{perf, APAP} (min^-1)
Male	0.468 (16.5)	0.588 (44.7)
Female	0.525 (31.1)	0.564 (36.3)
K_gluc (min^-1)^*
Male	0.183 (36.9)	0.199 (17.3)
Female	0.121 (16.5)	0.119 (8.2)
K_sulf (min^-1)^*
Male	0.007 (13.1)	0.009 (50.6)
Female	0.026 (8.8)	0.018 (44.6)
K_{perf, AG} (min^-1)
Male	0.168 (45.4)	0.247 (22.5)
Female	0.217 (49.3)	0.214 (77.3)
K_g1 (min^-1)
Male	0.044 (89.3)	0.104 (36.7)
Female	0.093 (49.4)	0.092 (55.3)
K_{bile, AG} (min^-1)^, ^*
Male	0.014 (45.4)	0.001 (66.4)
Female	0.002 (68.1)	0.001 (72.1)
K_{perf, AS} (min^-1)^*
Male	0.379 (38.6)	0.271 (11.7)
Female	0.663 (17.6)	0.634 (9.6)
K_s1 (min^-1)^*
Male	0.048 (25.3)	N.A.
Female	0.017 (39.5)	N.A.
K_{bile, AS} (min^-1)^*
Male	0.107 (8.0)	N.A.
Female	0.043 (72.6)	N.A.

CV, coefficient of variation; N.A., not available.

p < 0.05, male vs. female.

^**

p < 0.05, wild-type vs. Bcrp-deficient mice.