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. 2009 Jul 10;136(15):2545–2555. doi: 10.1242/dev.031781

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Fig. 3. — Otx2 is sufficient for the ectopic induction of Nkx6-1 and Pou4f1⁺ RN neurons. (A-L) Representative coronal sections from the rostral hindbrain of E9.5 (A,G) and E12.5 (B-F,H-L) WT (A-F) and En1^+/Wnt1 (G-L) embryos. (A,G) At E9.5, ectopic expression of Otx2 induces Nkx6-1 ectopically in the FP of the En1^+/Wnt1 rostral hindbrain. (D,J) Ectopic Nkx6-1⁺ cells are located lateral to the Otx2⁺ domain (inset in J; Nkx6-1 in red, Otx2 in green) in the En1^+/Wnt1 rostral hindbrain FP at E12.5. (E,K) Ectopic Pou4f1⁺ cells arise from the Otx2⁺/Shh⁺/Nkx6-1⁺ mutant FP. (F,L) Isl1⁺ cells are not detected at this caudal level of the WT and mutant brain. Plane of sectioning in B-F and H-L is more horizontal than in the inset in J.