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. 2009 Jun 5;136(13):2141–2151. doi: 10.1242/dev.033175

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Fig. 3. — Transcriptional control of HC and amacrine cell development. The transcription factor Foxn4 lies at the top of the genetic hierarchy that regulates HC and amacrine cell fate determination in mice and probably also in other vertebrates. Downstream of Foxn4, the transcription factor Ptf1a reinforces the decision towards either amacrine or HC fate. The transcription factor Prox1 steers a subset of Ptf1a⁺ cells towards the HC fate, whereas transcription factors Math3 and NeuroD direct a separate cohort towards the amacrine cell fate. Further downstream in the amacrine cell developmental pathway, the transcription factors Barhl2, Bhlhb5 and Isl1 specify subtypes of amacrine cell. See text for details on the other factors. HC, horizontal cell; AC, amacrine cell; BP, bipolar cell; MG, Müller glial cell; GC, ganglion cell; R, rod photoreceptor; C, cone photoreceptor; RPC, retinal progenitor cell.