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. 2009 May 27;136(13):2177–2186. doi: 10.1242/dev.035329

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Fig. 4. — Excessive Notch pathway activity leads to transient accumulation of FSC derivatives. (A-D) Ovarioles with positively marked (green nuclei) FSC clones expressing UAS-N^intra or UAS-Su(H)VP16 and stained with FasIII (red). Both N^intra (A) and Su(H)VP16 (B) cause FSC loss and ectopic accumulation of FasIII-expressing FSC derivatives that generally separate from the germarium without being incorporated into egg chambers. Loss of Ptc (C) or Ptc and Mam (D) from FSC clones exacerbates the accumulation of FSC derivatives due to N^intra or Su(H)VP16, even though FSCs are still frequently lost.