Table 4.
Ectopic Notch pathway activity depletes FSCs and does not rescue mam mutant FSCs
|
Percentage of ovarioles with marked FSC clones
|
|||||
|---|---|---|---|---|---|
|
7 Days
|
14 Days
|
||||
| Genotype* | Total | AM | Total | AM | Normalized total (14 days) |
| Control | 61 | 7 | 41 | 14 | 100 |
| UAS-Nintra (strong) | 23 | 1 | 17 | 0 | 41 |
| Control | 54 | 6 | 59 | 16 | 100 |
| UAS-Su(H)VP16 (strong) | 57 | 4 | 27 | 1 | 46 |
| Control | 51 | 2 | 39 | 10 | 100 |
| UAS-Nintra | 26 | 1 | 22 | 0 | 56 |
| mam | 26 | 0 | 8 | 0 | 21 |
| mam;UAS-Nintra | 18 | 0 | 8 | 0 | 21 |
| ptc | 57 | 16 | 48 | 24 | 123 |
| ptc;UAS-Nintra | 35 | 1 | 29 | 2 | 74 |
| ptc mam | 22 | 0 | 13 | 0 | 33 |
| ptc mam;UAS-Nintra | 23 | 0 | 14 | 0 | 36 |
| Control | 57 | 2 | 48 | 13 | 100 |
| UAS-Su(H)VP16 | 33 | 0 | 23 | 0 | 48 |
| mam | 25 | 0 | 11 | 0 | 23 |
| mam;UAS-Su(H)VP16 | 15 | 0 | 9 | 2 | 19 |
| ptc | 61 | 11 | 48 | 21 | 100 |
| ptc;UAS-Su(H)VP16 | 34 | 0 | 25 | 0 | 52 |
| ptc mam | 19 | 0 | 12 | 0 | 25 |
| ptc mam;UAS-Su(H)VP16 | 18 | 0 | NC | ||
AM, percentage ovarioles with `all marked' FSC derivatives.
NC, not counted due to poor morphology from degeneration.
*
UAS transgenes were driven by tub-GAL4 only, except where `strong' denotes addition of E22C-GAL4 and Act-GAL4 drivers.