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. 2009 Aug 27;4(8):e6796. doi: 10.1371/journal.pone.0006796

Figure 8. PPARα serves as a global transcriptional regulator of lipid metabolism in mouse and human hepatocytes.

Figure 8

Genes significantly upregulated by Wy14643 and that function in lipid metabolism were classified into specific metabolic pathways. Separate pictures were created for human hepatocytes (A) and mouse hepatocytes (B). Genes significantly upregulated by Wy14643 at both time points of 6 h and 24 h are shown in bold. Genes significantly upregulated by Wy14643 in human and mouse hepatocytes are shown in red. Genes significantly upregulated by Wy14643 at one time point only are shown in normal font. Functional classification is based on a self-made functional annotation system of genes involved in lipid metabolism.