Figure 6. Ingenuity pathway analysis (IPA) network representation of the highly scored network.

The genes that are shaded red are up-regulated and those that are green are down-regulated. The intensity of the color shows the degree of up-or down-regulation. A solid line represents a direct interaction while a dotted line represents an indirect interaction between the two gene products (A). Working Model: Increased expression of UCH L1 in malignant cells leads to cell cycle progression, increased proliferation and migration and at the same time abrogation of apoptotic pathways and immune responses and thus promotes tumor progression (B).