Table 4.
Diet, feces, and absorption (diet-feces) of energy, fat, carbohydrate, and protein.
| (mean ± SD, n = 8) | 1st year | 2nd year | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | Week 13 | Week 26 | Week 52 | Washout | Week 13 | Week 26 | Week 52 | P-value* | |
| Treatment | None | GLP-2 | GLP-2 | GLP-2 | None | GLP-2 | GLP-2 + Cholyl-sarcosine# | GLP-2 | |
|
| |||||||||
| Energy (kJ/d) | |||||||||
| Diet | 14810 ± 6429 | 14421 ± 5556 | 14958 ± 5485 | 14001 ± 5445 | 15277 ± 5926 | 13729 ± 5369 | 13658 ± 4821 | 13494 ± 4025 | .69 |
| Feces | 5928 ± 5305 | 5400 ± 3968 | 5799 ± 4095 | 5240 ± 3668 | 6332 ± 4197 | 4838 ± 3469 | 4075 ± 2866 | 4555 ± 2596 | .02 |
| Abs. absorption | 8882 ± 3339 | 9021 ± 2500 | 9159 ± 2151 | 8761 ± 2461 | 8945 ± 2655 | 8892 ± 2786 | 9583 ± 2649 | 8940 ± 2419 | .82 |
| Rel. absorption | 64 ± 18 | 66 ± 16 | 64 ± 13 | 65 ± 12 | 61 ± 16 | 66 ± 15 | 72 ± 12 | 67 ± 14 | .03 |
| Fat (g/d) | |||||||||
| Diet | 103 ± 43 | 113 ± 44 | 114 ± 46 | 103 ± 40 | 109 ± 46 | 104 ± 44 | 98 ± 45 | 103 ± 42 | .22 |
| Feces | 67 ± 62 | 69 ± 61 | 70 ± 58 | 61 ± 58 | 78 ± 63 | 58 ± 56 | 39 ± 40 § | 54 ± 47 | .005 |
| Abs. absorption | 36 ± 35 | 44 ± 25 | 44 ± 20 | 42 ± 33 | 31 ± 29 | 46 ± 28 | 59 ± 26 | 48 ± 24 | .11 |
| Rel. absorption | 43 ± 34 | 48 ± 36 | 46 ± 29 | 50 ± 37 | 35 ± 36 | 50 ± 33 | 64 ± 27 § | 50 ± 34 | .002 |
| Carbohydrate (g/d) | |||||||||
| Diet | 374 ± 145 | 345 ± 128 | 354 ± 129 | 341 ± 126 | 382 ± 140 | 342 ± 129 | 355 ± 107 | 369 ± 102 | .62 |
| Feces | 66 ± 60 | 57 ± 43 | 59 ± 40 | 57 ± 37 | 70 ± 42 | 52 ± 33 | 50 ± 31 | 51 ± 19 | .08 |
| Abs. absorption | 308 ± 109 | 288 ± 97 | 295 ± 100 | 284 ± 96 | 311 ± 106 | 290 ± 107 | 306 ± 81 | 318 ± 90 | .53 |
| Rel. absorption | 84 ± 9 | 84 ± 6 | 84 ± 5 | 84 ± 5 | 83 ± 6 | 85 ± 5 | 87 ± 4 | 86 ± 3 | .18 |
| Protein (g/d) | |||||||||
| Diet | 105 ± 51 | 101 ± 48 | 107 ± 44 | 96 ± 52 | 115 ± 54 | 99 ± 41 | 95 ± 39 | 102 ± 41 | .15 |
| Feces | 50 ± 35 | 46 ± 31 | 47 ± 27 | 46 ± 29 | 57 ± 35 | 43 ± 34 | 42 ± 22 | 43 ± 22 | .08 |
| Abs. absorption | 55 ± 36 | 54 ± 31 | 60 ± 25 | 49 ± 33 | 58 ± 33 | 56 ± 29 | 53 ± 33 | 59 ± 32 | .76 |
| Rel. absorption | 52 ± 22 | 55 ± 19 | 57 ± 13 | 50 ± 18 | 51 ± 21 | 55 ± 19 | 54 ± 18 | 56 ± 18 | .50 |
*Friedman repeated measures analysis of variance on ranks in patients completing the study. For comparisons of admission periods to the baseline period, the Dunnett method was used as the post hoc test. § ~ P < .05. #Cholylsarcosine was given two days prior to the admission and during the 72-hour balance studies.