Table 1. Overview of brain samples.
NBB number (*) | Autopsy nr | gender | age | Disease | Braak stage | Post mortem delay (h:m) | Brain pH | brain weight (grams) | APOE haplotype | region used | MAPT haplotype | Disease duration (years) | Cause of death | Chip ID | Figure ID |
96–098 | S96/289 | f | 72 | Progressive supranuclear palsy | 5∶20 | 6.25 | 1213 | 43 | medial temporalis gyrus | H1/H1 | 7 | pulmonary arrest | IB31 | PSP5 | |
96–119 | S96/340 | m | 72 | Progressive supranuclear palsy | 5∶48 | 6.71 | 1160 | 33 | medial temporalis gyrus | H1/H1 | 9 | dehydration and respiratory insufficiency | IB29 | PSP3 | |
97–072 | S97/191 | m | 57 | Progressive supranuclear palsy | 5∶43 | 6.42 | 1396 | 33 | medial temporalis gyrus | H1/H1 | 6 | pneumonia and cachexia by PSP | IB28 | PSP2 | |
99–050 | S99/120 | f | 93 | Progressive supranuclear palsy | 2 | 4∶15 | 6.32 | 1048 | 33 | medial temporalis gyrus | H1/H1 | 3 | cachexia and dehydration | IB30 | PSP4 |
00–086 | S00/180 | m | 73 | Progressive supranuclear palsy | 8∶55 | 7.20 | 1408 | 42 | medial temporalis gyrus | H1/H1 | 2 | euthanasia | IB27 | PSP1 | |
00–096 * | S00/203 | m | 73 | Progressive supranuclear palsy | 5∶20 | 7.04 | 1204 | 43 | medial temporalis gyrus | H1/H1 | 3 | pneumonia/cachexia | IB64 | ||
95–099 * | S95/287 | f | 57 | Progressive supranuclear palsy | 8∶10 | 6.75 | 1391 | 33 | medial temporalis gyrus | H1/H1 | 4 | septic with a urinary infection | IB55 | ||
AD | |||||||||||||||
00–140 | S00/318 | f | 72 | Alzheimer's disease | 6 | 3∶45 | 6.61 | 1070 | 43 | medial temporalis gyrus | H1/H1 | 15 | dehydration | IB35 | AD4 |
00–099 | S00/206 | f | 78 | Alzheimer's disease | 6 | 3∶35 | 6.93 | 935 | 33 | medial temporalis gyrus | H1/H2 | 7 | unknown | IB34 | AD3 |
00–044 | S00/085 | f | 80 | Alzheimer's disease | 6 | 5∶20 | 6.68 | 946 | 44 | medial temporalis gyrus | H1/H1 | unspecified (7+) | general deterioration | IB32 | AD1 |
01–091 | S01/206 | m | 73 | Alzheimer's disease | 6 | 5∶00 | 6.68 | 1075 | 43 | medial temporalis gyrus | H1/H1 | 10 | cachexia following swallowing disturbances | IB33 | AD2 |
00–066 | S00/141 | m | 80 | Alzheimer's disease | 6 | 4∶20 | 7.08 | 1240 | 43 | medial temporalis gyrus | H2/H2 | 7 | dehydration and vascular insufficiency | IB36 | AD5 |
95–069 * | S95/181 | m | 68 | Alzheimer's disease | 6 | 4∶15 | 6.65 | 1446 | 44 | medial temporalis gyrus | H1/H1 | 8 | aspiration pneumonia | IB60 | |
89–073 * | S89/208 | m | 82 | Alzheimer's disease | 6 | 3∶25 | 6.64 | 1010 | 43 | medial temporalis gyrus | H1/H1 | 13 | cachexia and dehydration | IB59 | |
CONTR | |||||||||||||||
01–028 | S01/078 | f | 78 | Non-demented control | 1 | 4∶50 | 6.40 | 1250 | 33 | medial temporalis gyrus | H1/H1 | - | myocardial infarction | IB39 | CONTR3 |
00–142 | S00/320 | f | 82 | Non-demented control | 1 | 5∶30 | 6.60 | 1280 | 32 | medial temporalis gyrus | H1/H1 | - | myocardial infarction | IB37 | CONTR1 |
98–101 | S98/196 | m | 72 | Non-demented control | 6∶45 | undefined | 1383 | 43 | medial temporalis gyrus | H1/H1 | - | heart failure | IB38 | CONTR2 | |
99–116 | S99/249 | m | 78 | Non-demented control | 4∶20 | undefined | 1310 | 33 | medial temporalis gyrus | H1/H1 | - | pancreatic cancer | IB40 | CONTR4 | |
01–021 | S01/064 | m | 82 | Non-demented control | 1 | 7∶40 | 6.07 | 1373 | 33 | medial temporalis gyrus | H1/H2 | - | heart attack | IB41 | CONTR5 |
Pick C1 | |||||||||||||||
96–064 | S96/179 | m | 78 | Pick's disease (Const. type C1) | 5∶00 | 6.64 | 1354 | 43 | medial temporalis gyrus | H1/H1 | 12 | sepsis, due to an urinary tract infection, and cachexia | IB17 | FTD1 | |
03–049 | S03/137 | f | 64 | Pick's disease (Const. type C1) | 5∶10 | 6.53 | 1002 | 43 | medial temporalis gyrus | H1/H1 | 3 | respiratory insufficience | IB18 | FTD2 | |
96–094 | S96/277 | f | 72 | Pick's disease (Const. type C1) | 3∶55 | 6.90 | 1243 | 43 | medial temporalis gyrus | H1/H1 | 8 | cachexia and dehydration | IB19 | FTD3 | |
98–029 | S98/046 | m | 74 | Pick's disease (Const. type C1) | 5∶10 | 6.49 | 1223 | 33 | medial temporalis gyrus | H1/H1 | 14 | infection of lungs | IB20 | FTD4 | |
98–119 | S98/223 | m | 74 | Pick's disease (Const. type C1) | 3∶45 | 6.55 | 951 | 43 | medial temporalis gyrus | H1/H2 | 11 | pneumonia in a dehydrated and cachexic patient | IB21 | FTD5 | |
97–051 * | S97/158 | m | 75 | Pick's disease (Const. type C1) | 5∶30 | 7.50 | 1069 | 33 | medial temporalis gyrus | H1/H2 | 12 | bronchopneumonia | IB63 | ||
Pick A | |||||||||||||||
98–075 | S98/162 | f | 77 | Pick's disease (Const. type A) | 5∶20 | 6.21 | 967 | 33 | medial temporalis gyrus | H1/H2 | 4 | complications secondary to a cerebro vasculair accident | IB22 | PID1 | |
98–159 | S98/283 | f | 83 | Pick's disease (Const. type A) | 5∶10 | 6.90 | 715 | 43 | medial temporalis gyrus | H1/H1 | 16 | acute cardiac arrest | IB23 | PID2 | |
95–086 | S95/244 | m | 64 | Pick's disease (Const. type A) | 4∶40 | 6.53 | 1353 | 33 | medial temporalis gyrus | H1/H1 | 6 | myocardial infarction | IB24 | PID3 | |
02–062 | S02/185 | m | 70 | Pick's disease (Const. type A) | 5∶15 | 6.53 | 1201 | 33 | medial temporalis gyrus | H1/H2 | 15 | aspiration pneumonia | IB25 | PID4 | |
96–012 | S96/027 | f | 64 | Pick's disease (Const. type A) | 7∶55 | 6.50 | 1260 | 33 | medial temporalis gyrus | H1/H2 | 6 | bleeding of the stomach | IB26 | PID5 | |
98–163 * | S98/284 | f | 61 | Pick's disease (Const. type A) | 6∶15 | 6.18 | 1148 | 44 | medial temporalis gyrus | H1/H2 | 8 | lungdisorder with fever for 4 weeks | IB62 |
Overview of characteristics of all brain samples used in this paper. *Samples that were used for the verification experiment.