Table 2.
Risk of fracture by DBP haplotypes of DBP codon 416–420 in 6,181 elderly individuals
| Total | Haplotypes of DBP codon 416–420 | P | |||
|---|---|---|---|---|---|
| Noncarrier | Heterozygous | Homozygous | |||
| Haplotype 1 (Gc1 s) | |||||
| Case/total (%) | 905/6,181 (14.6) | 155/1,183 (13.1) | 456/3,068 (14.9) | 294/1,930 (15.2) | 0.13* |
| Crude HR (95% CI) | 1 | 1.16 (0.95–1.41) | 1.19 (0.97–1.41) | 0.13* | |
| Adjusted HR (95% CI)# | 1 | 1.13 (0.93–1.38) | 1.20 (0.97–1.49) | 0.13* | |
| Haplotype 1 carrier | |||||
| Case/total (%) | 155/1,183 (13.1) | 750/4,998 (15.0) | 0.10 | ||
| Adjusted HR (95% CI)# | 1 | 1.16 (0.96–1.40) | 0.13 | ||
| Haplotype 2 (Gc2) | |||||
| Case/total (%) | 482/3,221 (15.1) | 348/2,477 (14.0) | 72/483 (14.9) | 0.56 | |
| Crude HR (95% CI) | 1 | 0.92 (0.80–1.07) | 0.99 (0.76–1.29) | 0.56 | |
| Adjusted HR (95% CI) | 1 | 0.89 (0.77–1.04) | 0.95 (0.72–1.25) | 0.35 | |
| Haplotype 3 (Gc1f) | |||||
| Case/total (%) | 649/4,348 (14.9) | 239/1,686 (14.2) | 17/147 (11.6) | 0.24* | |
| Crude HR (95% CI) | 1 | 0.94 (0.80–1.10) | 0.74 (0.45–1.24) | 0.24* | |
| Adjusted HR (95% CI) | 1 | 0.95 (0.81–1.12) | 0.84 (0.50–1.42) | 0.42* | |
#HR was adjusted for age and gender
* Trend P value estimated by linear regression analysis