Fig. 7.
Re-exposure to the IS context enhanced the FR-2 escape deficit. FLX treatment improved escape performance of animals re-exposed to the IS context. The bold line represents the period of drug administration after IS. Data are expressed as group mean escape failures±SEM at each test session. (n=7–8 per group). Following IS, rats were either left in their home cage (controls), re-exposed to the IS context (re-exposure) for 10 min every third day, or re-exposed to the context while receiving daily FLX (5 mg/kg/day) (re-exposure + FLX). Animals re-exposed to the IS context had more escape failures, regardless of treatment, compared to the control group at test session 1. At test session 2, the re-exposure group had significantly more escape failures than controls. At test session 3, the re-exposure + FLX group had fewer escape failures than the re-exposure group. Escape performance improved linearly across test sessions in FLX treated animals. *p<0.001 compared to control, ‡p<0.001 compared to control, **p<0.05 compared to control, #p=0.06 compared to re-exposure, ptrend<0.01