Table 2.

Comparative Pathogenesis of HVP2ap and HVP2nv in 129 and IFNAR^−/− Mice¹

			2 DPI				3 DPI				4 DPI
			Histopathology		Virus Isolation		Histopathology		Virus Isolation		Histopathology		Virus Isolation
Mouse Strain	Virus	Mouse No.	Skin	Lumbar DRG	Skin	Lumbar DRG	Skin	Lumbar DRG	Skin	Lumbar DRG	Skin	Lumbar DRG	Skin	Lumbar DRG
129	HVP2nv	1	1+	0	4.3e4	0	3+	2+	1.9e4	1.0e4	4+	4+	2.0e4	4.4e3
		2	1+	0	6.2e3	0	4+	0	2.7e4	1.3e3	1+	2+	6.5e5	2.0e5
		3	2+	0	5.7e4	0	4+	2+	2.1e4	5.0e3	0	3+	8.0e4	2.0e5
		Mean±SEM			3.5±1.5e4	0			2.2±0.3e4	5.4±2.5e3			2.5±2.0e5	1.3±0.6e5
	HVP2ap	1	1+	0	2.2e3	0	1+	0	3.5e2	0	0	2+	3.8e4	0
		2	2+	0	6.2e3	0	3+	0	2.9e3	0	1+	1+	5.9e4	5.1e3
		3	0	0	1.5e4	0	2+	1+	9.0e3	1.4e3	NS*	2+	4.3e4	6.2e2
		Mean±SEM			7.8±3.8e3	0			4.1±2.6e3	4.7±4.5e2			4.7±0.6e4	1.9±1.6e3
IFNAR−/−	HVP2nv	1	3+	0	6.7e6	0	4+	1+	1.4e6	0	4+	3+	1.4e6	9.6e5
		2	0	0	2.7e6	0	3+	1+	1.1e6	4.9e5	4+	4+	5.4e5	6.5e5
		3	1+	0	1.0e6	0	2+	0	1.6e5	6.7e3	3+	1+/-	1.2e6	1.3e6
		Mean±SEM			3.5±1.7e6	0			8.9±3.7e5	1.7±1.6e5			1.0±0.3e6	9.7±1.9e5
	HVP2ap	1	3+	0	2.1e6	0	4+	2+	5.8e5	4.3e3	4+	3+	2.3e6	1.3e6
		2	2+	0	3.1e6	0	4+	0	7.4e5	5.7e3	4+	2+	2.4e5	3.4e5
		3	2+	0	1.3e6	0	2+	0	1.4e6	1.0e3	4+	2+	1.4e6	2.6e5
		Mean±SEM			2.2±0.5e6	0			9.1±2.5e5	3.7±1.4e3			1.3±0.6e6	6.3±3.3e5

^*NS, no sample.

¹Groups of 6 mice were infected by skin scarification. At each time point, 3 mice were used to quantitate infectious virus in the skin or lumbar spinal cord and associated DRGs, and 3 mice were used for histopathological examination.