Table 1.
Treatment | VSV titer (pfu/mg tumor) | ||
---|---|---|---|
PC61 | 0 | 0 | 0 |
VSV | 500 | 100 | 500 |
IL-2/VSV | 5 × 103 | 103 | 8 × 103 |
PC61/IL-2/VSV | 2 × 106 | 3 × 105 | 9 × 105 |
Abbreviations: IL-2, interleukin-2; pfu, plaque forming units; Treg, regulatory T cells; VSV, vesicular stomatitis virus.
Tumor-bearing C57Bl/6 mice (three/group) were treated as shown in Figure 3a. Thirty-six hours after the injection of VSV, the tumors were explanted and analyzed; the viral titers recovered from the freeze–thaw lysates for each tumor are shown.