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. Author manuscript; available in PMC: 2009 Aug 20.
Published in final edited form as: Mol Ther. 2008 Apr 22;16(7):1217–1226. doi: 10.1038/mt.2008.83

Table 1.

Treg depletion combined with IL-2 facilitates replication of intravenously delivered VSV within the tumor

Treatment VSV titer (pfu/mg tumor)
PC61 0 0 0
VSV 500 100 500
IL-2/VSV 5 × 103 103 8 × 103
PC61/IL-2/VSV 2 × 106 3 × 105 9 × 105

Abbreviations: IL-2, interleukin-2; pfu, plaque forming units; Treg, regulatory T cells; VSV, vesicular stomatitis virus.

Tumor-bearing C57Bl/6 mice (three/group) were treated as shown in Figure 3a. Thirty-six hours after the injection of VSV, the tumors were explanted and analyzed; the viral titers recovered from the freeze–thaw lysates for each tumor are shown.