Table 3.
Characteristic of 139 patients with type 1 diabetes divided according to the median urine IgM level into low (<0.01 mg/mol) and high IgM (>0.01 mg/mol) groups.
| Variable | Low IgM group | High IgM group | P value |
| At baseline: | |||
| Sex (male/female) | 71 (49/22) | 68 (30/38) | 0.003 |
| Age (years) | 35(18-74) | 37(20-80) | 0.05 |
| Duration of diabetes (yr) | 15 (1-65) | 24 (1-67) | 0.001 |
| HbA1c % | 8.3 (4.5-13.4) | 9 (5.5-13.2) | 0.06, ns |
| Albuminuria (mg/mmol) | 3.6(0.23-268) | 21.3 (0.26-640) | <0.001 |
| S. Creatinine μmol/l | 78 (54-216) | 86 (42-486) | 0.009 |
| GFR (ml/min/1.73 m2) | 88 (27-141) | 67(9-144) | <0.001 |
| MAP mmhg | 93 (80-120) | 100 (78-133) | 0.004 |
| ACEI/ARBs, n/n (%) | 3/2 (7.1%) | 15/6 (31%) | <0.001 |
| During follow-up: | |||
| Follow up time (years) | 19 (2-22) | 14 (1-22) | <0.001 |
| MAP mmhg | 97 (73-119) | 103 (73-147) | 0.038 |
| HbA1c (%) | 8.25 (4.5-13.9) | 8 (4.5-13.4) | |
| 0.7, ns | |||
| Albuminuria (mg/mmol) | 1.3 (0.1-676) | 20.5 (0.1-1101) | <0.001 |
| ACEI/ARBs, n/n (%) | 12/14 (37%) | 22/17 (59%) | 0.008 |
| CV-Mortality rate per patient-year | 0.005838 | 0.029104 | <0.001 |
| Renal failure rate per patient-year | 0.003451 | 0.022161 | 0.003 |
Abbreviations: ACEI: Angiotensin converting enzyme inhibitors; ARBs: Angiotensin II receptor antagonists; CV: cardiovascular; ESRD: End stage renal disease; GFR: glomerular filtration rate; HbA1c: glycosylated hemoglobin; MAP: Mean arterial blood pressure.