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. Author manuscript; available in PMC: 2009 Sep 9.
Published in final edited form as: Neuroscience. 2008 Jun 17;155(4):1204–1211. doi: 10.1016/j.neuroscience.2008.05.059

Figure 4. Over expression of exogenous EAAT2 in astrocytes enhances neuroprotection against oxygen glucose deprivation.

Figure 4

Neuronal damage mediated by OGD was measured by propidium iodide (PI) uptake in control RHSCs exposed to OGD (open white bars); RHSCs not exposed to OGD (stippled bars); RHScs transduced with AAV1-GFAP-null virus (solid black bars); RHSCs transduced with AAV1-GFAP-EAAT2 transduced (gray bars) and RHSCs treated with 100µM penicillin G (horizontal stripped bars). Panel A shows RHSCs exposed to moderate to OGD and imaged for PI fluorescence at 18, and 24 hours post OGD (n=10–13 slices). Panle B shows RHSCs exposed to sever insult and imaged for PI fluorescence at 18, and 24 hours post OGD (n=10–21 slices). (One-way ANOVA analysis, ** = p < 0.01)