Figure 6.

Comparison of non-obese diabetic (NOD) mice that were injected weekly with parasite antigen (LsAg, n= 5) and controls. (a) Percentages of diabetic mice (glucose > 230 mg/dl) over time and (b) number of pancreatic islets counted from four slides. Pancreatic islets were classified into non-infiltrated, peri-insulitis and intrainsulitis with less than or greater than 50% infiltrating lymphocytes. (c) Concentrations of total immunoglobulin E (IgE; left panel) and levels of insulin-specific IgG1 (right panel) in the sera of mice. (d) Concentrations of interleukin-4 (IL-4), IL-10 and interferon-γ (IFN-γ) in spleen cell culture supernatants in response to α-CD3/α-CD28. Significant differences were analysed by Mann–Whitney U-test (*P < 0·05).