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. Author manuscript; available in PMC: 2009 Aug 20.
Published in final edited form as: Int J Biochem Cell Biol. 2007 Oct 23;40(4):565–575. doi: 10.1016/j.biocel.2007.10.018

Fig. 1.

Fig. 1

A plausible interpretation of pRb2/P130-mediated ER-α transcription regulation in human breast cancer MCF-7 cell line. The upper part of the panel shows a permissive configuration for ER-α transcription, in which a multi-molecular complex comprising pRb2/p130, HDAC1, SUV39H1 and HAT interacts with the ER-α promoter. The lower part of the panel shows a non-permissive configuration for ER-α transcription. In this case, DNMT1 is present in the multi-molecular complex, whereas HAT is released. Abbreviations: HDAC1 = histone deacetylase 1; DNMT1 = DNA (cytosine-5) methyltransferase 1; HAT = histone acetyltransferase; SUV39H1 = histone methyltransferase; TAFs = transcription activating factors; RNA pol II = RNA polymerase II; TBP = TATA binding protein. Transcription factors are reported as: IIA, IIB, IIF, IIH and IIE.