TABLE 1.

The authors’ comparison of antidepressants for the treatment of neuropathic pain

ANTIDEPRESSANTS	EFFICACY	EVIDENCE-BASED SUPPORT	DOSE	SIDE EFFECT LOADING
+++ = High; ++ = Moderate; + = Low
Note: This summary reflects the authors’ interpretation of the available data.
Tertiary amine tricyclic antidepressants (amitriptyline, doxepin, imipramine)	Yes	+++	Low to Standard	+++
Venlafaxine	Yes	++	Standard	+
Duloxetine	Yes	++	Standard	+
Bupropion	Yes	+	Standard	+
Secondary amine tricyclic antidepressants (desipramine, nortriptyline)	Yes	++	Low to Standard	+++
Paroxetine, citalopram	Modest	+	Standard	+
Fluoxetine	No	--	Standard	+