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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Nature. 2009 Jul 5;460(7257):909–913. doi: 10.1038/nature08210

Figure 4. LIN28 expression in human germ cell tumours.

Figure 4

a, Primary malignant germ cell tumours of multiple histologies show consistent high expression of LIN28 and LIN28B. Benign teratomas and normal testis show no significant expression of LIN28 or LIN28B. Mixed germ cell tumour (GCT); yolk-sac tumour (YST); Choriocarcinoma (C); Embryonal carcinoma (EC); Seminoma (S); Teratoma (Ter); and Normal testis (Tes). b, Immunohistochemical detection of LIN28 in primary embryonal carcinoma. Left panel: Cytoplasmic immunoreactivity of embryonal carcinoma cells for LIN28 (between arrowheads). Endodermal epithelial elements of the teratoma (arrows) and tumoural stroma are not immunoreactive. Middle panel: Higher magnification of immunoreactive embryonal carcinoma. Adjacent seminiferous tubules are negative (between arrows). Right panel: Intratubular germ cell neoplasia within the embryonal carcinoma demonstrates LIN28 immunoreactivity. (40× magnification).