Time course of sodium excretion (UNaV, nEq/min/gKW) during infusions of huUgnA (filled squares, left column) or huUgnB (filled circles, right column) in the amounts indicated (nmol/kg BW). Peptides were infused during the time periods indicated by the horizontal bars. Rats in the control group (open triangles) received isotonic saline alone during the infusion period. Values are means ± SEM for each 20 min clearance period. Two-way ANOVA testing with post hoc comparisons was used to test significance of peptide responses against control values at various time points, as indicated in the boxes (blank = p>0.05 (not significant), * = p<0.05, ** = p<0.01, *** = p<0.001).