Table 2. Baseline Matrix Remodeling Biomarkers and Four-Year Incidence of Blood Pressure Outcomes.

Matrix Biomarkers	Mean (Standard deviation)	Number at risk	Percentage of Individuals developing hypertension		Percentage of Individuals with increase by ≥1 blood pressure category
			Unadjusted	Age- and sex-adjusted*	Unadjusted	Age- and sex-adjusted*
TIMP tertile
T1	643.3 (45.6)	198	8.1	9.9	24.75	26.9
T2	750.5 (29.3)	199	10.6	11.1	32.66	33.2
T3	896.1 (94.6)	198	22.2	18.6	42.42	39.3
PIIINP tertile
T1	2.03 (0.50)	182	8.8	10.7	28.6	30.6
T2	3.05 (0.26)	181	14.4	13.4	32.6	31.7
T3	7.08 (6.85)	182	15.4	14.0	36.2	35.1
MMP-9 category
Non-detectable	0	290	13.5	13.9	32.8	33.1
Detectable	45.5 (32.7)	61	24.6	21.8	50.8	49.1

Blood pressure categories: optimal blood pressure, systolic<120 mm Hg and diastolic<80 mm Hg; normal blood pressure, systolic 120-129 mm Hg or diastolic 80-84 mm Hg; high-normal blood pressure, systolic 130-139 mm Hg or diastolic 85-89 mm Hg.

TIMP-1: tissue inhibitor of metalloprotein-1; MMP-9: matrix metalloprotein-9; PIIINP: procollagen III N terminal peptide

^*Values are age- and sex-adjusted proportions using logistic regression (sample mean age of 54.6 years and 39% are men).