Table 4. Relations of Matrix Remodeling Biomarkers to Hypertension and Progression of Blood Pressure category in Individuals with < 50th Sex-specific Percentile of LVDD and LVWT.

Markers of Matrix Remodeling	Models
	TIMP-1
	Incidence of Hypertension		Progression of Blood Pressure Category
	Age- sex- adjusted	Multivariable-adjusted*	Age- sex- adjusted	Multivariable-adjusted*
	Odds ratio (95% CI)	Odds ratio (95% CI)	Odds ratio (95% CI)	Odds ratio (95% CI)
Log TIMP-1, per SD incremen	1.15 (0.82-1.62)	1.32 (0.88-1.99)	1.28 (1.02-1.61)	1.31 (1.04-1.66)
Tertile 1	Referent	Referent	Referent	Referent
Tertile 2	1.02 (0.43-2.43)	0.58 (0.22-1.55)	1.64 (0.96-2.78)	1.47 (0.85-2.53)
Tertile 3	1.72 (0.76-3.91)	1.72 (0.70-4.20)	2.02 (1.17-3.48)	1.98 (1.13-3.46)
Trend	0.18	0.18	0.01	0.02
	PIIINP
Log PIIINP, per SD increment	1.10 (0.78-1.55)	1.21 (0.83-1.77)	0.92 (0.75-1.13)	0.94 (0.76-1.16)
Tertile 1	Referent	Referent	Referent	Referent
Tertile 2	1.18 (0.49-2.82)	1.28 (0.47-3.47)	0.95 (0.56-1.63)	0.91 (0.52-1.60)
Tertile 3	0.85 (0.33-2.19)	1.03 (0.34-3.11)	0.97 (0.56-1.70)	1.00 (0.56-1.77)
Trend	0.71	0.96	0.93	0.99
	MMP-9
Non-detectable MMP-9	Referent	Referent	Referent	Referent
Detectable MMP-9	1.96 (0.55-6.92)	3.08 (0.60-15.77)	1.74 (0.73-4.10)	2.60 (1.01-6.69)

^*All multivariable models are adjusted for age, sex, systolic and diastolic blood pressure, BMI, percentage weight change, smoking and diabetes mellitus. TIMP-1: tissue inhibitor of metalloprotein-1; MMP-9: matrix metalloprotein-9; PIIINP: procollagen III N terminal peptide. CI denotes confidence intervals.