Appendix Table 1. Baseline Characteristics According to Tertiles of TIMP-1 and PIIINP.

Characteristic	Total	Tertiles of TIMP-1			Tertiles of PIIINP

		Tertile 1	Tertile 2	Tertile 3	Tertile 1	Tertile 2	Tertile 3
*Clinical Data*
Age, yrs	54.6±8.9	52.1±7.2	54.0±8.3	57.7±10.1	52.6±8.0	55.9±8.6	55.7±9.7
Women, %	60.5	68.2	62.3	51.0	61.0	62.4	59.3
Body mass index, kg/m²	26.1±4.6	25.1±3.9	26.1±4.4	27.2±5.2	25.3±3.9	25.9±4.2	27.4±5.5
Systolic blood pressure, mm Hg	117±12	114±12	118±12	118±11	115±12	117±12	118±12
Diastolic blood pressure, mm Hg	72±8	71±8	73±8	73±8	72±8	72±8	73±8
Optimal BP, %	55.5	63.1	50.8	52.5	59.3	51.4	54.4
Normal BP %	24.0	22.7	25.6	23.7	20.9	30.4	20.3
Diabetes, %	3.5	2.5	3.0	5.1	1.7	3.3	5.5
Current cigarette smoking, %	16.5	15.7	17.1	16.7	22.5	12.2	13.7
Weight change, %	1.0	1.3±5.6	0.5±6.6	1.0±6.0	1.1±6.9	0.8±6.0	0.9±5.3
LVDD and LVWT, below sex-specific 50^th percentile, %	72.8	78.3	72.4	67.7	75.8	72.9	67.6
LVDD or LVWT, above 90^th percentile, %	27.2	21.7	27.6	32.3	24.2	27.1	32.4
*Matrix remodeling markers, ng/mL*
TIMP-1, ng/ml median (IQR)	752.5 (155.3)	652.6 (62.0)	752.5 (55.5)	870.0 (87.8)	714.2 (132.2)	756.9 (150.9)	775.7 (161.8)
PIIINP, ng/ml median (IQR)	3.05 (1.49)	2.76 (1.45)	3.06 (1.46)	3.28 (1.54)	2.13 (0.68)	3.05 (0.44)	4.56 (2.20)
MMP-9, % detectable	17.4	21.4	17.9	13.6	14.2	14.1	25.3

All values are mean ± standard deviation or otherwise indicated

Optimal blood pressure, systolic <120 mm Hg and diastolic <80 mm Hg; normal blood pressure, systolic 120-129 mm Hg or diastolic 80-84 mm Hg; high normal blood pressure, systolic 130-139 mm Hg or diastolic 85-89 mm Hg.

TIMP-1: tissue inhibitor of metalloproteinase-1; MMP-9: matrix metalloproteinase-9; PIIINP: procollagen III N-terminal peptide

LVDD: left ventricular internal diastolic dimension; LVWT: left ventricular wall thickness