Figure 1.
A. Sample scatter plots are shown illustrating the identification of whole blood iNKT cell populations. After gating on the lymphocyte population (identified by forward and side light scatter) and CD3+ lymphocytes (T cells), iNKT cells were identified and quantified in all control and patient samples by co-expression of TCRVα24 and TCRVβ11, and in selected samples also by recognition of PBS57-loaded CD1d tetramer. As shown here, simultaneous staining with TCRVα24 and TCRVβ11 and PBS57-loaded CD1d tetramer demonstrates that both methods identify the same population. B. iNKT cell populations were studied in 7 randomly selected control samples using both co-expression of TCRVα24 and TCRVβ11 and by recognition of PBS57-loaded CD1d tetramer to aid in the validation of each method. Results as listed.
