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Methylphosphonate substitution studies on UDG catalysis and transition state inhibitor binding. (A) The relative kcat values for the fast (f) and slow (s) migrating methylphosphonate stereoisomers are indicated. (B) 1-Azadeoxyribose oxacarbenium ion mimics. Each phosphodiester linkage was substituted with a methylphosphonate group to remove the charge, and the relative KD values compared to the all phosphodiester analogue were measured.
