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. Author manuscript; available in PMC: 2009 Aug 20.
Published in final edited form as: Chem Rev. 2006 Aug;106(8):3443–3467. doi: 10.1021/cr050317n

Figure 23.

Figure 23

Linear free energy correlations for binding of the methylphosphonate substituted 1-azadeoxyribose analogues and deoxyuridine substrates111. The empty circles show the correlation between log kcat/Km for the methylphosphonate -substituted substrates and log KD for the corresponding methylphosphonate substituted 1-azadeoxyribose analogues. The slope of the line is −1. The filled circles show the correlation between log Km for the methylphosphonate -substituted substrates and log KD for the corresponding MeP-substituted 1-azadeoxyribose analogues. The slope of this line is 0.5.