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. Author manuscript; available in PMC: 2009 Aug 20.
Published in final edited form as: Chem Rev. 2006 Aug;106(8):3443–3467. doi: 10.1021/cr050317n

Figure 8.

Figure 8

Interactions between MS2 coat protein and RNA 56. (A) Representation of the protein-phosphate contacts observed in the crystal structure of the complex of MS2 coat protein bound to a 21-nucleotide RNA hairpin. The prefixes A and B specify the amino acids in the two monomers of the dimeric coat protein. O1 and O2 correspond to the Rp and Sp phosphorothioate diastereomers. (B) Thio effects on binding. Black triangles indicate the positions with the largest thio effects of binding; upward and downward pointing triangles indicate stronger and weaker binding for the phosphorothioate RNA, respectively. Small effects are indicated by white triangles, and sites where binding was unaffected by substitution are marked with an x.