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. Author manuscript; available in PMC: 2009 Aug 20.
Published in final edited form as: Chem Rev. 2006 Aug;106(8):3443–3467. doi: 10.1021/cr050317n

Table 3.

Bridging Thio Effects (TEB) on vTopo DNA Cleavagea

Enzyme TEB
Wt 0.7
H265A 1.8
R130A 190
R130K 2,600
K167A 370
R130K:K167A 2,000
R223A 0.8
a

From refs 94 and 95. TEB (bridging thio effect) = kox/ks.