Figure 2.

Risedronate impedes the invasiveness of SaOS-2 and U2OS cells (A and B). A 10-well chemotaxis chamber was used to measure the effect of risedronate on invasiveness. A Matrigel-coated membrane was inserted between the upper and lower chambers, and stained using a Hemacolor rapid staining kit. Stained areas represented numbers of migrating cells. The numbers in the panels show the concentration of risedronate added. Images are representative of three independent experiments. Bars (C) represent cells number (expressed as percentages of controls) of each image ± standard deviation.