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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Ann N Y Acad Sci. 2009 Jul;1170:664–673. doi: 10.1111/j.1749-6632.2009.04373.x

Figure 1. Regulation of adult neurogenesis by various types of neural activity.

Figure 1

(A) Schematic representation of a sagittal view of the adult mouse brain. New neurons are generated continuously throughout life in the subventricular zone (SVZ)-olfactory bulb (OB) system and the dentate gyrus (DG) of the hippocampus.

(B) Activity-dependent neurogenesis in the adult olfactory bulb. Transient amplifying cells give rise to neuroblasts, migrating toward the OB through the rostral migratory stream (RMS). Within the OB, these neuroblasts differentiate into two types of interneurons as the granule cell and periglomerular cell (PGC). Integration into the pre-existing circuits by newly entered neurons and their survival are predominantly influenced by odor experiences, such as enriched odor exposure or odor discriminate learning.

(C) Activity-dependent neurogenesis in the dentate gyrus. Neural progenitors in the SGZ proliferate and differentiate into neuroblasts that migrate a short distance into the inner granular cell layer, processes that are modulated by various types of neural activity. The survival and integration of new neurons is also regulated in an activity-dependent manner.