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. 2009 Jun 10;330(3):704–717. doi: 10.1124/jpet.109.155010

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Fig. 12. — Ovariectomy does not change the effects of β₃AR agonists TAK-677 and BRL37344 in bladder strips. A, summary of the effects of TAK-677 on baseline tone in OVX (white bars; n = 25 strips) and in SHAM (black bars; n = 25 strips) rats. B, summary of the effects of TAK-677 on amplitude of spontaneous contractions in OVX (white bars; n = 25 strips) and in SHAM (black bars; n = 25 strips) rats. No statistically significant differences were seen between SHAM and OVX for any of the concentrations tested. C and D, comparisons between the effects of TAK-677 (black bars; n = 25 strips) and the effects of BRL37344 (gray bars; n = 10 strips) on baseline tone (C) and on amplitude of spontaneous contractions (D) in OVX rats. For all panels, * indicate significant changes from control tested using ANOVA followed by Tukey-Kramer post hoc test. # indicates statistically significant changes between the effect of TAK-677 and the effect of BRL37344 tested with unpaired t test.