Fig. 7.

Ovariectomy alters the voiding pattern of urethane-anesthetized rats. A, parameters used for quantifying the effects of drugs on voiding in a typical CMG recording: A, ICI, PTh, and BP. B, examples of voiding patterns recorded in the control period before adding drugs in a SHAM (i) and in two OVX rats (ii, iii, and iv). Note that OVX rats are more irregular (ii) have nonvoiding contractions between voidings (iii, iv), and the ICI is shorter. iv shows an expansion of the dashed area in iii. C, summary of ICIs of OVX (n = 13), SHAM (n = 11), RB (n = 20), and virgin (V; n = 14) rats before drug treatment. Bar graphs show the mean values for each group, and individual symbols show data from individual rats. Asterisks indicate statistically significant difference between the groups indicated in figure (unpaired t test p < 0.05). ns stands for statistically not significant. Comparisons between groups other that those indicated in the figure were not statistically significant.