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. 2009 Jun 2;330(3):783–791. doi: 10.1124/jpet.109.154146

Fig. 2.

Fig. 2.

Pharmacological stimulation of the E193K mutant. A to C, representative short-circuit current recordings from transfected FRT cells showing response of the E193K-CFTR mutant to different concentrations of felodipine, PG-01, and SF-01. Before addition of potentiators, cells were stimulated with maximal forskolin (20 μM). At the end of the experiments, CFTR-dependent currents were blocked with CFTRinh-172 (10 μM). D, dose-response relationships for the three potentiators. Each point is the average ± S.E.M. of six to nine experiments. Data were fitted with a Hill equation. inh-172, CFTRinh-172.