Fig. 3.

Pharmacological stimulation of the G970R mutant. A to C, short-circuit current recordings from transfected FRT cells showing response of the G970R-CFTR mutant to potentiators as in Fig. 2. C, a single concentration of felodipine (10 μM) was added after the SF-01 dose response. B, inset shows that the current activated by PG-01 and partially inhibited by CFTR_inh-172 (10 μM) can be further inhibited close to zero (dotted line) by GlyH-101 (50 μM). D, dose-response relationships for the three potentiators. Each point is the average ± S.E.M. of 9 to 10 experiments. inh-172, CFTR_inh-172.