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Sustained morphine treatment augments basal cAMP formation in DRG cells. Mor, treatment of cultured neonatal rat DRG neurons with 1 μM morphine for 24 h augmented basal cAMP formation to 231 ± 27% of control (*, p < 0.05, one-sample t test; n = 4), which is an increase of 131% over the control. The results (mean ± S.E.M.) are expressed as the percentage of cAMP formation in control unstimulated DRG neurons.
