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. 2009 Jun 22;330(3):884–891. doi: 10.1124/jpet.109.154468

Fig. 3.

Fig. 3.

Inhibition of the cGMP-hydrolytic activity in cytosolic fractions of failing human left ventricular myocardium by sildenafil. cGMP-hydrolytic activity was measured at 0.1 μM cGMP in the presence of 200 μM Ca2+ and 50 nM calmodulin or in the presence of 100 μM EGTA. Each value represents the average ± S.D. of at least three determinations.