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The irreversible FAAH inhibitor URB597 reduced allodynia in mice subjected to CCI. Mice were injected intraperitoneally with URB597. A, mechanical allodynia was tested 60 min after drug treatment via von Frey test. B, cold allodynia was tested 90 min after drug treatment via acetone-induced cold allodynia test. ○, control paw; •, CCI paw. Data expressed as mean ± S.E.M. (n = 8–10). ** p < 0.01 versus vehicle-treated paw.
