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. 2009 Aug 31;4(8):e6869. doi: 10.1371/journal.pone.0006869

Figure 1. Generation of Prom1 knock-in mice and reporter analysis in the central nervous system.

Figure 1

(A) Schematic representation of targeted allele. (B) Southern blot analysis of three independent heterozygous lines. (C) Whole mount X-gal staining of E12.5 Prom1lacZ,DTA/+ and WT embryos. Scale, 2 mm. (D) X-gal staining of frozen sections of adult mouse brains. Upper panel shows the whole brain and lower five panels display high magnification images of the squared regions in the upper panel. GM, glomeruli; CC, corpus callosum; LV, lateral ventricle; FH, fimbra of hippocampus; GL, granular layer. Scale, 2 mm (upper panel) and 500 µm (lower panels).