Table 3.

Common Doses and Levels of Older and Newer AEDs

	Adult Dosage/Day	Levels (uG/mL)
Older AEDs
Carbamazepine	400-1600+ mg (600 mg)	4-12+
Ethosuximide	500-1500+ mg	40-100+
Phenobarbital	90-180+ mg	15-40
Phenytoin	200-400+ mg	8-20+
Primidone	500-1500+ mg	5-12 (measure phenobarbital)
Valproate	750-2500+ mg	50-100+
Newer AEDs
Felbamate	1800-4800+ mg	30-100+
Gabapentin	900-3600+ mg	4-20++
Lacosamide	200-600+ mg	?
Lamotrigine	300-600+ mg	1-20+
Levetiracetam	1000-3000++ mg	5-40++
Oxcarbazepine	600-3600+ mg	10-40+ (measure MHD)
Rufinamide	400-3200 mg	?
Tiagabine	16-64 mg	100-300 ng/mL
Topiramate	100-600+ mg	10-20+
Zonisamide	100-600+ mg	10-40+

uG/mL= micrograms/milliliter.

⁺= higher doses/levels often additionally effective, as tolerated.

⁺⁺= considerably higher doses/levels sometimes additionally effective in intractable patients, as tolerated.

MHD = 10, 11 Monohydroxyderivative active metabolite of oxcarbazepine.

nG/mL = nanograms/milliliter.

^?= no evidence yet available to indicate typically therapeutic level since drug is newly approved.