Table 4.
AED Adjustments in Context of Levels and Clinical Status
| AED Levels | Efficacy | Side Effects | AED Adjustment? |
|---|---|---|---|
| Super therapeutic Or Sub therapeutic | Seizure-free | None | No |
| Super therapeutic Or Sub therapeutic | AED responder | Tolerable | Raise dose |
| Super therapeutic Or Sub therapeutic | Seizure-free | Intolerable | Lower dose; move to new/next AED trial |
| Super therapeutic Or Sub therapeutic | Intractable | Tolerable AEs | Raise dose if no response plateau |
| Super therapeutic Or Sub therapeutic | Intractable | Intolerable AEs | Lower dose; move to new/next AED trial; ?epilepsy surgery/VNS |
| Therapeutic | Seizure-free | No AEs | No |