TABLE 1.
Overall characteristics of women eligible for analysis
| Characteristics | Overall cohort | (n=1620) | Recommend PMRT | (n=238) | Do not recommend PMRT | (n=1029) | Consider PMRT | (n=329) |
|---|---|---|---|---|---|---|---|---|
| Patient characteristics, median (25th–75th percentile) | ||||||||
| Age, years | 52.8 | (44.5–63.1) | 52.5 | (42.5–63.2) | 55.0 | (48.0–64.7) | 45.6 | (40.3–52.1) |
| Distance (miles) from radiation facility | 7.03 | (3.27–13.54) | 7.79 | (3.41–12.46) | 6.93 | (3.14–13.40) | 7.35 | (3.52–14.71) |
| Income (thousands of dollars) | 45.7 | (35.6–60.5) | 46.1 | (35.4–61.1) | 45.5 | (35.3–59.9) | 46.6 | (36.6–60.7) |
| Caucasian, % | 82.9 | (1343) | 79.0 | (188) | 83.8 | (862) | 83.0 | (273) |
| Managed care | 57.5 | (932) | 55.5 | (132) | 55.6 | (572) | 65.4 | (215) |
| At least some college education | 50.0 | (810) | 46.6 | (111) | 49.5 | (509) | 55.9 | (184) |
| Employed | 43.1 | (698) | 41.2 | (98) | 40.2 | (414) | 54.4 | (179) |
| 2 or more co–morbidities | 9.1 | (147) | 8.4 | (20) | 9.3 | (96) | 7.9 | (26) |
| Clinical characteristics | ||||||||
| Tumor size: | ||||||||
| 0–2.0 cm | 61.2 | (991) | 29.8 | (71) | 71.9 | (740) | 50.2 | (165) |
| 2.1–5.0 cm | 36.2 | (586) | 60.0 | (142) | 28.1 | (289) | 46.5 | (153) |
| > 5.0 cm | 1.3 | (21) | 8.8 | (21) | 0 | - | 0 | - |
| Number of positive axillary lymph nodes: | ||||||||
| 0 | 54.5 | (883) | 11.3 | (27) | 82.0 | (844) | 3.0 | (10) |
| 1–3 | 28.3 | (459) | 2.9 | (7) | 18.0 | (185) | 79.6 | (262) |
| 4 or more | 16.1 | (260) | 85.3 | (203) | 0 | 17.3 | (57) | |
| Surgical margin status: | ||||||||
| negative | 97.5 | (1579) | 89.5 | (213) | 100 | (1029) | 95.1 | (313) |
| positive | 1.1 | (18) | 7.6 | (18) | 0 | - | 0 | - |
| close (<2 mm) | 1.4 | (22) | 2.9 | (7) | 0 | - | 4.6 | (15) |
| Lymphovascular invasion | 25.6 | (415) | 53.8 | (128) | 16.0 | (165) | 36.2 | (119) |
| High grade | 38.1 | (617) | 47.9 | (114) | 33.3 | (343) | 46.2 | (152) |
| Estrogen-receptor positive | 72.5 | (1175) | 77.7 | (185) | 72.4 | (745) | 70.2 | (231) |
| Ductal histology | 78.4 | (1270) | 70.6 | (168) | 78.7 | (810) | 83.6 | (275) |
| Treatments received | ||||||||
| Ever on a clinical treatment trial** | 15.9 | (258) | 19.3 | (46) | 12.3 | (127) | 25.5 | (84) |
| Chemotherapy | 63.0 | (1021) | 91.2 | (217) | 47.7 | (491) | 91.8 | (302) |
| Early reconstruction | 38.8 | (629) | 31.1 | (74) | 40.1 | (413) | 41.0 | (135) |
| Surgery at a NCCN institution | 86.8 | (1406) | 79.8 | (190) | 90.2 | (928) | 80.9 | (266) |
**
excludes trials specifying receipt or omission of radiation