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. 2009 Sep 8;7(9):e1000189. doi: 10.1371/journal.pbio.1000189

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Various mutations were tested for ability to suppress lethality of a cln3 bck2 rme1 {MET-CLN2} strain on +methionine medium. The parental strain (N497) is cln3 bck2 rme1 {MET-CLN2}; other strains (top to bottom: N452, N453, N451, N499, and N454) have one additional mutation as indicated. Serial 4-fold dilutions were spread on −methionine (where MET-CLN2 is expressed) or +methionine (where MET-CLN2 is repressed). The HOS3 gene encodes a histone deacetylase, but this histone deacetylase was not identified in our suppressor screen and serves as a negative control.