Table 2. Number of samples analyzed for each histological type and the number of mutations identified.
Tumor type | Histotype | Number of samples analysed | Number of GNAQ mutated samples | P-value Fisher's exact test) |
Blue neavi | 13 | 6 | ||
AML | 80 | 0 | 2,25E-06 | |
Bladder | Total | 39 | 0 | 8,42E-05 |
transitional cell carcinoma | 35 | 0 | ||
cell line | 4 | 0 | ||
Breast | Total | 148 | 0 | 7,79E-08 |
ductal carcinoma | 61 | 0 | ||
lobular carcinoma | 50 | 0 | ||
medullary carcinoma | 18 | 0 | ||
mucinous carcinoma | 19 | 0 | ||
Colorectal | adenocarcinoma | 119 | 0 | 2,62E-07 |
GIST | 22 | 0 | 1,06E-03 | |
Glioma | Total | 131 | 0 | 1,54E-07 |
glioblastoma | 117 | 0 | ||
anaplastic astrocytoma | 2 | 0 | ||
anaplastic oligodendroglioma | 2 | 0 | ||
high grade glioma cell lines | 14 | 0 | ||
Lung | Total | 134 | 0 | 1,36E-07 |
adenocarcinoma | 110 | 0 | ||
small cell carcinoma | 17 | 0 | ||
carcinoid | 7 | 0 | ||
Melanoma | Total | 24 | 0 | 7,38E-04 |
primary | 1 | 0 | ||
nodal metastasis | 14 | 0 | ||
cutaneous metastasis | 7 | 0 | ||
visceral metastasis | 2 | 0 | ||
Ovary | serous adenocarcinoma | 51 | 0 | 2,28E-05 |
Pancreas | ductal adenocarcinoma | 98 | 0 | 7,57E-07 |
Thyroid | Total | 63 | 0 | 7,85E-06 |
medullary carcinoma | 23 | 0 | ||
papillary carcinoma | 20 | 0 | ||
follicular carcinoma | 20 | 0 |
(AML: acute myeloid leukemia, GIST: Gastrointestinal Stromal Tumors; In addition, p-values of the Fisher's exact test, used to determine the tissue specificity for GNAQ Q209 mutations in blue naevi, are listed.)