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. 2009 Aug 31;4(8):e6833. doi: 10.1371/journal.pone.0006833

Table 2. Number of samples analyzed for each histological type and the number of mutations identified.

Tumor type Histotype Number of samples analysed Number of GNAQ mutated samples P-value Fisher's exact test)
Blue neavi 13 6
AML 80 0 2,25E-06
Bladder Total 39 0 8,42E-05
transitional cell carcinoma 35 0
cell line 4 0
Breast Total 148 0 7,79E-08
ductal carcinoma 61 0
lobular carcinoma 50 0
medullary carcinoma 18 0
mucinous carcinoma 19 0
Colorectal adenocarcinoma 119 0 2,62E-07
GIST 22 0 1,06E-03
Glioma Total 131 0 1,54E-07
glioblastoma 117 0
anaplastic astrocytoma 2 0
anaplastic oligodendroglioma 2 0
high grade glioma cell lines 14 0
Lung Total 134 0 1,36E-07
adenocarcinoma 110 0
small cell carcinoma 17 0
carcinoid 7 0
Melanoma Total 24 0 7,38E-04
primary 1 0
nodal metastasis 14 0
cutaneous metastasis 7 0
visceral metastasis 2 0
Ovary serous adenocarcinoma 51 0 2,28E-05
Pancreas ductal adenocarcinoma 98 0 7,57E-07
Thyroid Total 63 0 7,85E-06
medullary carcinoma 23 0
papillary carcinoma 20 0
follicular carcinoma 20 0

(AML: acute myeloid leukemia, GIST: Gastrointestinal Stromal Tumors; In addition, p-values of the Fisher's exact test, used to determine the tissue specificity for GNAQ Q209 mutations in blue naevi, are listed.)