Bile ducts were harvested from new born mice 2, 5, 7 and 14 days post infection with RRV and homogenized (n=3–7). Chemokine levels were determined by ELISA and expressed as means with standard error. Significantly higher levels of RANTES, KC, and MCP-1 were observed starting at day 5 and continuing through day 14 (p<0.05). RANTES and MCP-1 peaked at day 7 while KC peaked at day 5. MIP-2 was significantly higher at all time points tested (p<0.05), peaking at day 7.