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Base stacking interactions in the CGCG portions at both ends of the DDD (PDB entry BDL084) and DDDZ10 duplexes. The conformations of the tetramer duplexes in the structures of the DDD and DDDZ10 duplexes indicate adjustments in the relative orientations of the modified and flanking base pairs in the latter. The modified base pair in DDDZ10 and the respective base pair in the unmodified DDD duplex are colored black, and atom C7 of 7-deaza-dG is highlighted with a black ball.
